Argentina and Brazil cannot be faced until the final of the tournament but first Jorge Sampaoli’s side must beat the reigning champions after finishing top of Group A
Should La Roja defeat the Celeste – who do not look like the side who conquered the competition four years ago – then they would face Bolivia or Peru in the last four, dodging Brazil, Argentina, Colombia and Paraguay until at least the final.
Host nation Chile are the competition’s top scorers with 10 from their three games as Jorge Sampaoli’s side booked their place in the last eight by topping Group A.
Having taken four points off Ecuador and Mexico, Sampaoli’s men hammered Bolivia 5-0 to set up a quarter-final tie with a Uruguay team yet to hit such heights, claiming just four points in their group campaign.
The defending champions have only scored twice – the long-term absence of suspended striker Luis Suarez undoubtedly a contributing factor – although captain Diego Godin returns from suspension for the match in Santiago.
While Tabarez can welcome back influential skipper Godin into his back line, full-back Alvaro Pereira will serve a suspension after accumulating two yellow cards.
It is up front where Tabarez has problems, with Edinson Cavani struggling to fire in a central position. Reports suggest that the Uruguay boss could opt for a three-man defence with Cristian Rodriguez used as one of two full-backs.
The city of Santiago was shut temporarily on Monday due to smog concerns, although things have since improved in the capital, with Godin playing down any fears over the pollution.
“We saw on TV about the pollution but we have not discussed anything with the doctor,” Godin said, before turning his attentions to the pressures that Chile may face.
“Chile are favourite. They are local and want to win the title for the first time, they are with their people and have that pressure. We know it is their opportunity to earn a historic title.”