Moussa Sissoko has been ruled out until April following knee surgery and joins Harry Kane, Hugo Lloris, Ben Davies and Tanguy Ndombele on the sidelines.
Jan Vertonghen could start at left-back here should Jose Mourinho elect to revert to a 4-2-3-1 system, though Ryan Sessegnon is an option for the Spurs boss. Danny Rose is also hopeful of coming into contention of facing the league leaders.
Erik Lamela is in contention for a first start since October with Son Heung-Min set to start in attack.
Nathaniel Clyne, Fabinho, James Milner and Naby Keita all miss the trip to Tottenham.
Joel Matip, Dejan Lovren and Xherdan Shaqiri are all closing in on returns to fitness, but the trip to north London is likely to come too soon for the trio.
Alex Oxlade-Chamberlain is expected to start in midfield, though Adam Lallana is an option for Jurgen Klopp.
- Tottenham have been poor of late, winning just one of their last five matches in all competitions. They had to come from behind to rescue their FA Cup tie at Middlesbrough and their recent record against Liverpool is thoroughly underwhelming.
- The Reds, meanwhile, are unbeaten in 37 league matches and have won 11 of their last 12 in all competitions, with the sole blip on the record coming in their Carabao Cup defeat at Aston Villa. Having kept a clean sheet in their last five league matches, Liverpool have the means to shut out a Tottenham side without star striker Harry Kane.
- Spurs may have lost only two home league matches this season, but a rampant Liverpool side are backed to come away with all three points.