Frenkie De Jong should start in the middle of midfield for Barcelona after picking up a LaLiga suspension.
Alvaro Morata and Joao Felix will face competition from Sergio Camello for their places in attack.
Koke and Angel Correa should feature out wide, with Thomas Lemar currently out of favour.
Jose Gimenez will face competition from Mario Hermoso for his place at centre-back.
Barcelona took a 1-0 win over Atletico Madrid in December, with Luis Suarez assisting Lionel Messi’s winner.
Ernesto Valverde’s side have drawn three of their last four games, however, keeping just one clean sheet.
Atletico Madrid have won their last four outings, conceding just twice in the process.