Rostov have lost only once in their last seven European home games and even beat Bayern Munich in the Champions League group stages at the start of the season.
The Russian side warmed up for this fixture with a 6-0 win against Tom Tomsk.
Manchester United have kept four successive clean sheets in the Europa League, only Napoli have ever managed five in a row.
United have drawn six of their nine meetings with Russian sides in the past and a tough game is expected here. Naija and Bet
FC Rostov – First choice goalkeeper Soslan Dzhanaev has not featured since December and could miss out on Thursday.
No unexpected changes are expected from the Russian side.
Manchester United – Jose Mourinho has some big decisions to make ahead of their trip to Russia on Thursday with an FA Cup clash with Chelsea only four days later. The Manchester United manager has also revealed he has plenty to think about when selecting his side after seeing the state of the pitch they will play on.
Eric Bailly is suspended for the first leg against FC Rostov, but Henrikh Mkhitaryan appears to have recovered from the muscle injury that has kept him out of their last two matches after being included in the travelling squad.
There was no room for Luke Shaw, who his first appearance in over a month at the weekend, Wayne Rooney and Bastian Schweinsteiger.
Zlatan Ibrahimovic serves a three-game domestic ban but will feature in both legs of their Europa League tie, while Ander Herrera and Chris Smalling were unused substitutes against Bournemouth and will return to the side on Thursday.
Man Utd have kept a clean sheet in their last 4 matches in UEFA Europa League
Man Utd have won 6 of their last 7 UEFA Europa League matches.
How will this Match end?